Full Name

Protein kinase CK2

Tumor Types

NSCLC

Function

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene.

GeneCards Link

Complete Relavant Tumor Types

Breast Cancer

Oncomine gene expression profiling data (fold change, cancer vs. normal)

Three Selected Reference

1. Association of protein kinase CK2 inhibition with cellular radiosensitivity of non-small cell lung cancer. Sci Rep.2017 Nov 23;7(1):16134

2. Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice Cancer Res. 2018 Oct 1;78(19):5644-5655.

3. Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling Leukemia. 2017 Jul;31(7):1603-1610

Score