Welcome to Checkpoint Therapeutic Targets and Modulators Database (CKTTD) for Cancer Immunotherapy

Immune checkpoints are regulators of the immune system which prevents the immune system from attacking cells indiscriminately. Tumor cells could become immune-tolerant via tumor microenvironment or immune editing of checkpoint targets. Therefore, checkpoint targets play a key role in tumor-mediated immune escape and might be potential drug targets for the cancer immunotherapy. CKTTD is a comprehensive database which collects checkpoint targets in cancer immunotherapy as well as their modulators (small-molecules or antibody) with validated experimental evidences curated from existing literatures. Moreover, a scoring system was incorporated to evaluate the verified levels and enhance the confidence of checkpoint targets for cancer immunotherapy. A few key novel features are highlighted below

cancer-types cloud map


Curated articles:
Target entries:
Modulator entities:
miRNA entries:
LncRNAs entities:
Cancer types:
Related Pathways:

About us: Yuan Yao, yao_yuan@live.com; Caigang Liu, angel-s205@163.com; Yongliang Yang, everbright99@foxmail.com

School of Bioengineering & School of Software, Dalian University of Technology, China
Cancer Hospital of China Medical University, Shenyang, China
Shengjing Hospital of China Medical University, Shenyang, China