We adopted a scoring system in the curations to
evaluate the verified levels and enhance the confidence of immune checkpoint targets.
The confidence score is based on the number of publications and sample types
(tissues or cell lines) used for experiments. For each target, we calculated
the confidence score as follows, Score =
N * (C + T), in which N is the number of studies/publications
that verified the targets, C and T refer to if the target has been
verified in cancer cell lines or patient (or animal) tissues, respectively.
Namely, if the target has been verified in cancer cell lines or patient tissues,
the C or T value will be set to 1, respectively. Hence, a high score means
that the target is more relevant with high confidence. This score could be used
for researchers to identify interesting targets with more confidence for research
and drug discovery.